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Interleukin 7 induces preferential expansion of V beta 8.2+CD4-8- and V beta 8.2+CD4+8- murine thymocytes positively selected by class I molecules.白细胞介素7诱导由I类分子阳性选择的Vβ8.2 + CD4 - 8 - 和Vβ8.2 + CD4 + 8 - 小鼠胸腺细胞优先扩增。
J Exp Med. 1994 Aug 1;180(2):653-61. doi: 10.1084/jem.180.2.653.
2
Involvement of 4F2 antigen expressed on the MHC-negative target cells in the recognition of murine CD3+CD4-CD8- alpha beta (V alpha 4/V beta 2) T cells.MHC阴性靶细胞上表达的4F2抗原参与小鼠CD3⁺CD4⁻CD8⁻αβ（Vα4/Vβ2）T细胞的识别。
Int Immunol. 1994 Sep;6(9):1323-31. doi: 10.1093/intimm/6.9.1323.
3
Requirement of IL-7 for IL-4-producing potential of MHC class I-selected CD4-CD8-TCR alpha beta+ thymocytes.
Int Immunol. 1997 Jan;9(1):73-9. doi: 10.1093/intimm/9.1.73.
4
MHC class I-selected CD4-CD8-TCR-alpha beta+ T cells are a potential source of IL-4 during primary immune response.MHC I类选择的CD4-CD8-TCR-αβ+ T细胞是初次免疫反应期间IL-4的潜在来源。
J Immunol. 1995 Nov 15;155(10):4544-50.
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Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4-8- subsets of natural killer 1.1+ T cell receptor-alpha/beta+ cells in the liver of mice.主要组织相容性复合体I类相关分子控制小鼠肝脏中自然杀伤1.1 + T细胞受体α/β +细胞的CD4 + 8-和CD4-8-亚群的发育。
J Exp Med. 1994 Aug 1;180(2):699-704. doi: 10.1084/jem.180.2.699.
6
Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules.p56lck酪氨酸激酶对未成熟CD4⁺CD8⁺胸腺细胞中T细胞受体表达的调控：在同时表达共受体分子的未成熟胸腺细胞中CD4和CD8差异信号传导的基础。
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Thymic selection and thymic major histocompatibility complex class II expression are abnormal in mice undergoing graft-versus-host reactions.在经历移植物抗宿主反应的小鼠中，胸腺选择和胸腺主要组织相容性复合体II类分子的表达是异常的。
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Concomitant Disruption of and Genes Facilitates the Development of Double Negative αβ TCR Peripheral T Cells That Respond Robustly to Staphylococcal Superantigen.和基因的同时破坏促进了对葡萄球菌超抗原强烈应答的双阴性αβ TCR外周T细胞的发育。
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Precommitment of CD4+CD8+ thymocytes to either CD4 or CD8 lineages.CD4+CD8+胸腺细胞向CD4或CD8谱系的预先定向。
Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):8982-6. doi: 10.1073/pnas.90.19.8982.
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Highly lytic CD8+, alpha beta T-cell receptor cytotoxic T cells with major histocompatibility complex (MHC) class I antigen-directed cytotoxicity in beta 2-microglobulin, MHC class I-deficient mice.在β2-微球蛋白、MHC I类缺陷小鼠中具有高度溶解性的CD8 +、αβT细胞受体细胞毒性T细胞，其具有针对主要组织相容性复合体（MHC）I类抗原的细胞毒性。
Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2837-41. doi: 10.1073/pnas.90.7.2837.

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Critical role of ROR-γt in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation.ROR-γt在一条新的胸腺途径中发挥关键作用，该途径导致产生白细胞介素-17的不变自然杀伤T细胞分化。
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J Exp Med. 2001 May 21;193(10):1221-6. doi: 10.1084/jem.193.10.1221.
5
Distinct roles for signals relayed through the common cytokine receptor gamma chain and interleukin 7 receptor alpha chain in natural T cell development.通过共同细胞因子受体γ链和白细胞介素7受体α链传递的信号在天然T细胞发育中的不同作用。
J Exp Med. 1997 Jul 21;186(2):331-6. doi: 10.1084/jem.186.2.331.
6
Lineage relationships and differentiation of natural killer (NK) T cells: intrathymic selection and interleukin (IL)-4 production in the absence of NKR-P1 and Ly49 molecules.自然杀伤（NK）T细胞的谱系关系与分化：在缺乏NKR-P1和Ly49分子的情况下胸腺内选择及白细胞介素（IL）-4的产生
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7
Essential requirement of an invariant V alpha 14 T cell antigen receptor expression in the development of natural killer T cells.自然杀伤T细胞发育过程中不变Vα14 T细胞抗原受体表达的基本要求。
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8
Stochastic coreceptor shut-off is restricted to the CD4 lineage maturation pathway.随机共受体关闭仅限于CD4谱系成熟途径。
J Exp Med. 1995 May 1;181(5):1623-33. doi: 10.1084/jem.181.5.1623.
9
Developmental arrest of NK1.1+ T cell antigen receptor (TCR)-alpha/beta+ T cells and expansion of NK1.1+ TCR-gamma/delta+ T cell development in CD3 zeta-deficient mice.CD3ζ缺陷小鼠中NK1.1⁺ T细胞抗原受体（TCR）α/β⁺ T细胞的发育停滞以及NK1.1⁺ TCRγ/δ⁺ T细胞发育的扩增。
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本文引用的文献

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NK1.1+ CD4+ CD8- thymocytes with specific lymphokine secretion.具有特异性淋巴因子分泌功能的NK1.1⁺ CD4⁺ CD8⁻ 胸腺细胞。
Eur J Immunol. 1993 Jan;23(1):307-10. doi: 10.1002/eji.1830230151.
2
A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.一条发育途径，涉及由CD44和CD25表达所定义的成年小鼠CD3⁻CD4⁻CD8⁻三阴性胸腺细胞的四个表型和功能不同的亚群。
J Immunol. 1993 May 15;150(10):4244-52.
3
Positive selection of V beta 8+ CD4-8- thymocytes by class I molecules expressed by hematopoietic cells.造血细胞表达的I类分子对Vβ8 + CD4 - 8 - 胸腺细胞的阳性选择。
J Exp Med. 1993 Sep 1;178(3):901-8. doi: 10.1084/jem.178.3.901.
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Keratinocyte-derived IL-7 serves as a growth factor for dendritic epidermal T cells in mice.角质形成细胞衍生的白细胞介素-7作为小鼠树突状表皮T细胞的生长因子。
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Phenotype analysis of cycling and postcycling thymocytes: evaluation of detection methods for BrdUrd and surface proteins.
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Interleukin-12 and its role in the generation of TH1 cells.白细胞介素-12及其在TH1细胞生成中的作用。
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Mice lacking the MHC class II-associated invariant chain.缺乏MHC II类相关恒定链的小鼠。
Cell. 1993 Feb 26;72(4):635-48. doi: 10.1016/0092-8674(93)90081-z.
8
Cutaneous lymphoproliferation and lymphomas in interleukin 7 transgenic mice.白细胞介素7转基因小鼠中的皮肤淋巴细胞增殖和淋巴瘤
J Exp Med. 1993 Feb 1;177(2):305-16. doi: 10.1084/jem.177.2.305.
9
A novel population of T-cell receptor alpha beta-bearing thymocytes which predominantly expresses a single V beta gene family.一种新的携带αβ型T细胞受体的胸腺细胞群体，其主要表达单个Vβ基因家族。
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Limited diversity of gamma delta antigen receptor genes of Thy-1+ dendritic epidermal cells.Thy-1+树突状表皮细胞γδ抗原受体基因的多样性有限。
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白细胞介素7诱导由I类分子阳性选择的Vβ8.2 + CD4 - 8 - 和Vβ8.2 + CD4 + 8 - 小鼠胸腺细胞优先扩增。

Interleukin 7 induces preferential expansion of V beta 8.2+CD4-8- and V beta 8.2+CD4+8- murine thymocytes positively selected by class I molecules.

作者信息

Vicari A, de Moraes M do C, Gombert J M, Dy M, Penit C, Papiernik M, Herbelin A

机构信息

INSERM U345, Institut Necker, Paris, France.

出版信息

J Exp Med. 1994 Aug 1;180(2):653-61. doi: 10.1084/jem.180.2.653.

DOI:10.1084/jem.180.2.653
PMID:8046338
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2191612/
Abstract

We analyzed the phenotype and V beta-T cell receptor (TCR) repertoire, together with interleukin 7 receptor (IL-7R) expression in unfractionated thymocytes stimulated in vitro with IL-7. This culture system results in a specific proliferation of mature thymocytes belonging to the CD3+CD4-, CD4+8-, and CD4-8+ subsets. IL-7 induced a preferential expansion of V beta 8.2+CD4-8- and V beta 8.2+CD4-8- thymocytes. This phenomenon is not observed in beta 2-microglobulin-deficient mice, showing that a fraction of CD4+8- thymocytes, enriched in V beta 8.2+ cells, is selected by class I molecules in normal mice, as are a large proportion of CD4-8- alpha beta TCR+ thymocytes. Our findings also establish that IL-7 plays a major role in the expansion of rare thymocyte subsets, which could exert important functions in inflammatory and immune responses.

摘要

我们分析了经白细胞介素7（IL-7）体外刺激的未分级胸腺细胞的表型、Vβ-T细胞受体（TCR）库，以及白细胞介素7受体（IL-7R）的表达情况。该培养系统导致属于CD3+CD4-、CD4+8-和CD4-8+亚群的成熟胸腺细胞特异性增殖。IL-7诱导Vβ8.2+CD4-8-和Vβ8.2+CD4-8-胸腺细胞优先扩增。在β2-微球蛋白缺陷小鼠中未观察到这种现象，这表明在正常小鼠中，富含Vβ8.2+细胞的一部分CD4+8-胸腺细胞是由I类分子选择的，很大比例的CD4-8-αβTCR+胸腺细胞也是如此。我们的研究结果还证实，IL-7在罕见胸腺细胞亚群的扩增中起主要作用，这些亚群可能在炎症和免疫反应中发挥重要功能。