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低雌激素剂量复方口服避孕药的临床试验(作者译)

[Clinical trial of a combined oral contraceptive with low estrogen dose (author's transl)].

作者信息

Schmidt-Elmendorff H W

出版信息

MMW Munch Med Wochenschr. 1975 Feb 28;117(9):345-8.

PMID:804642
Abstract

309 women took a combined oral contraceptive (0.04 mg ethinylestradiol and 2.0 mg lynestrol) in 1876 cycles under clinical supervision. The preparation was extremely well tolerated. Pregnancy did not occur; In 57 cases the administration of the tablets was concluded prematurely, but side effects were given as the reason for this discontinuation of the contraceptive in only 6.5% of the cases. Withdrawal bleeding lasted 3.9 days in the control cycle and 3.7 days in the 6th treatment cycle. Breakthrough bleeding occurred in 0.3% of the women.

摘要

1876个周期中,309名女性在临床监督下服用了复方口服避孕药(0.04毫克炔雌醇和2.0毫克炔雌醇甲醚)。该制剂耐受性极佳。未发生妊娠;57例中片剂服用提前结束,但仅6.5%的病例将副作用作为停用避孕药的原因。对照周期中撤退性出血持续3.9天,第6个治疗周期中为3.7天。0.3%的女性出现突破性出血。

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