西非结核病、疟疾、乙型肝炎和艾滋病之间的血清流行病学关联。

Seroepidemiological associations between tuberculosis, malaria, hepatitis B, and AIDS in West Africa.

作者信息

Adebajo A O, Smith D J, Hazleman B L, Wreghitt T G

机构信息

Rheumatology Research Unit, Addenbrooke's Hospital, Cambridge, United Kingdom.

出版信息

J Med Virol. 1994 Apr;42(4):366-8. doi: 10.1002/jmv.1890420407.

DOI:10.1002/jmv.1890420407

PMID:8046426

Abstract

Serum samples from 51 patients with malaria, 35 patients with hepatitis B virus infection, 111 patients with tuberculosis, and 166 healthy controls were studied to determine any associations between tuberculosis, malaria, hepatitis B, and AIDS in Nigeria, West Africa. All serum samples were examined for the presence of HIV-1/HIV-2, hepatitis B virus surface antigen (HBsAg), and malaria antibodies. Only one patient was HIV-1 antibody-positive and none HIV-2 antibody-positive. Statistical associations were found between the presence of malaria antibody titres on the one hand and a diagnosis of hepatitis B virus infection (P < 0.05) or tuberculosis (P < 0.05). A stronger association (P < 0.001) was found between the presence of HBsAg and tuberculosis suggesting that HBsAg carriers are at higher risk of contracting tuberculosis.

摘要

对来自51名疟疾患者、35名乙型肝炎病毒感染患者、111名结核病患者和166名健康对照者的血清样本进行了研究，以确定在西非尼日利亚结核病、疟疾、乙型肝炎和艾滋病之间的任何关联。所有血清样本均检测了HIV-1/HIV-2、乙型肝炎病毒表面抗原（HBsAg）和疟疾抗体的存在情况。仅1名患者HIV-1抗体呈阳性，无HIV-2抗体呈阳性。一方面，发现疟疾抗体滴度的存在与乙型肝炎病毒感染诊断（P < 0.05）或结核病诊断（P < 0.05）之间存在统计学关联。在HBsAg的存在与结核病之间发现了更强的关联（P < 0.001），这表明HBsAg携带者感染结核病的风险更高。