Solomon R E, VanRaden M, Kaslow R A, Lyter D, Visscher B, Farzadegan H, Phair J
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Am J Public Health. 1990 Dec;80(12):1475-8. doi: 10.2105/ajph.80.12.1475.
We examined the associations between seropositivity for hepatitis B virus (HBV) with the presence or development of antibodies to human immunodeficiency virus (HIV-1) and with HIV-1 induced T-helper lymphocyte deficiency or acquired immunodeficiency syndrome (AIDS). Serologic data on HBV and HIV-1, cytometric enumeration of CD4+ lymphocytes, clinical events (AIDS by Centers for Disease Control criteria) and hepatitis B vaccination histories were available on 4,498 homosexual participants in the Multicenter AIDS Cohort Study, Men were classified as to previous infection with HBV and prevalent or incident infection with HIV-1. Although there was an association between seropositivity for HBV infection and HIV-1 infection at enrollment (odds ratios anti-HBc 2.6; HBsAg 4.2), the relation between HBV seropositivity and subsequent seroconversion to HIV-1 was weaker (odds ratios 1.3 and 1.6). HIV-1 seroconversion was also associated with a history of certain other sexually transmitted diseases, but predisposing sexual practices did not account for the association between HBV and HIV-1 infection. Seropositivity for HBV infection at entry was not related to initially low or more rapid subsequent decline in T-helper lymphocyte counts and was not associated with an increased incidence of AIDS during 2.5 years of follow-up. History of vaccination against HBV did not appear to decrease susceptibility to HIV-1 infection or to subsequent progression of immunodeficiency. We conclude that prior HBV infection is unlikely to be specifically associated with acquisition of HIV-1 infection and is unrelated to more rapid progression of HIV-1-induced immunodeficiency.
我们研究了乙肝病毒（HBV）血清学阳性与人类免疫缺陷病毒（HIV-1）抗体的存在或产生以及与HIV-1诱导的T辅助淋巴细胞缺乏或获得性免疫缺陷综合征（AIDS）之间的关联。多中心艾滋病队列研究中4498名同性恋参与者有关于HBV和HIV-1的血清学数据、CD4 +淋巴细胞的细胞计数、临床事件（根据疾病控制中心标准诊断的AIDS）以及乙肝疫苗接种史。男性被分类为既往感染HBV以及HIV-1的现患或新发感染。尽管入组时HBV感染血清学阳性与HIV-1感染之间存在关联（抗-HBc的优势比为2.6；HBsAg为4.2），但HBV血清学阳性与随后HIV-1血清转化之间的关系较弱（优势比为1.3和1.6）。HIV-1血清转化也与某些其他性传播疾病的病史有关，但易感性行为并不能解释HBV与HIV-1感染之间的关联。入组时HBV感染血清学阳性与初始时较低或随后更快的T辅助淋巴细胞计数下降无关，并且与2.5年随访期间AIDS发病率增加无关。乙肝疫苗接种史似乎并未降低对HIV-1感染的易感性或免疫缺陷的后续进展。我们得出结论，既往HBV感染不太可能与HIV-1感染的获得有特异性关联，并且与HIV-1诱导的免疫缺陷更快进展无关。
