Kusuoka H, Hashimoto K, Fukuchi K, Nishimura T
Division of Tracer Kinetics, Osaka University Medical School, Japan.
J Nucl Med. 1994 Aug;35(8):1371-6.
This study focused on the kinetics of the newly developed 99mTc-nitroimidazole, propyleneamine oxime-1,2-nitroimidazole (BMS181321) in the different setting of myocardial perfusion states and oxygenation levels, and compared the kinetics of BMS181321 with those of other technetium analogues.
The kinetics of BMS181321 were evaluated in isolated perfused rat hearts. Technetium-99m-hexamethylpropyleneamine oxime (HMPAO) and a non-nitroimidazole-containing analogue of BMS181321 (6-methyl propyleneamine oxime; PAO-6-Me) were used to compare their kinetics with those of BMS181321.
BMS181321 cleared quickly from normoxic hearts and the retention in the myocardium 10 min after injection was 0.84% +/- 0.04% ID/g wet wt (mean +/- s.e.m.). In contrast, BMS181321 was retained after reperfusion when it was injected before ischemia; the uptake in the myocardium 10 min after reperfusion was significantly greater than in controls (23.9% +/- 3.9% ID/g wt, p < 0.05).
These results indicate that 99mTc-BMS181321 is well trapped in ischemic myocardium and moderately trapped in hypoxic myocardium, but washed out quickly in stunned myocardium. The residence time influences the amount retained.
本研究聚焦于新开发的99mTc-硝基咪唑，即丙二胺肟-1,2-硝基咪唑（BMS181321）在不同心肌灌注状态和氧合水平下的动力学，并将BMS181321的动力学与其他锝类似物进行比较。
在离体灌注大鼠心脏中评估BMS181321的动力学。使用99mTc-六甲基丙二胺肟（HMPAO）和BMS181321的一种不含硝基咪唑的类似物（6-甲基丙二胺肟；PAO-6-Me）将它们的动力学与BMS181321的动力学进行比较。
BMS181321从正常氧合心脏中清除迅速，注射后10分钟在心肌中的滞留率为0.84%±0.04% ID/g湿重（平均值±标准误）。相比之下，在缺血前注射BMS181321时，再灌注后其会滞留；再灌注后10分钟心肌中的摄取量显著高于对照组（23.9%±3.9% ID/g湿重，p<0.05）。
这些结果表明，99mTc-BMS181321在缺血心肌中滞留良好，在缺氧心肌中中度滞留，但在顿抑心肌中迅速洗脱。停留时间影响滞留量。
