Mees Gilles, Dierckx Rudi, Vangestel Christel, Van de Wiele Christophe
Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Eur J Nucl Med Mol Imaging. 2009 Oct;36(10):1674-86. doi: 10.1007/s00259-009-1195-9. Epub 2009 Jun 30.
Tissue hypoxia results from an inadequate supply of oxygen (O2) that compromises biological functions. Structural and functional abnormalities of the tumour vasculature together with altered diffusion conditions inside the tumour seem to be the main causes of tumour hypoxia. Evidence from experimental and clinical studies points to a role for tumour hypoxia in tumour propagation, resistance to therapy and malignant progression. This has led to the development of assays for the detection of hypoxia in patients in order to predict outcome and identify patients with a worse prognosis and/or patients that would benefit from appropriate treatments. A variety of invasive and non-invasive approaches have been developed to measure tumour oxygenation including oxygen-sensitive electrodes and hypoxia marker techniques using various labels that can be detected by different methods such as positron emission tomography (PET), single photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), autoradiography and immunohistochemistry. This review aims to give a detailed overview of non-invasive molecular imaging modalities with radiolabelled PET and SPECT tracers that are available to measure tumour hypoxia.
组织缺氧是由于氧气（O₂）供应不足而损害生物功能所致。肿瘤血管的结构和功能异常以及肿瘤内部扩散条件的改变似乎是肿瘤缺氧的主要原因。实验和临床研究的证据表明，肿瘤缺氧在肿瘤增殖、对治疗的抵抗和恶性进展中起作用。这导致了用于检测患者缺氧情况的检测方法的发展，以便预测结果并识别预后较差的患者和/或可能从适当治疗中受益的患者。已经开发了多种侵入性和非侵入性方法来测量肿瘤氧合，包括氧敏感电极和使用各种标记物的缺氧标记技术，这些标记物可以通过不同方法检测，如正电子发射断层扫描（PET）、单光子发射计算机断层扫描（SPECT）、磁共振成像（MRI）、放射自显影和免疫组织化学。本综述旨在详细概述可用于测量肿瘤缺氧的用放射性标记的PET和SPECT示踪剂的非侵入性分子成像模式。
