Vail D M, Panciera D L, Ogilvie G K
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison 53706.
J Vet Intern Med. 1994 Mar-Apr;8(2):122-7. doi: 10.1111/j.1939-1676.1994.tb03209.x.
Serum concentrations of thyroxine (T4), 3,5,3'-triiodothyronine (T3), free thyroxine (fT4), and free 3,5,3'-triiodothyronine (fT3) were compared between tumor-bearing dogs (with and without chronic weight loss) and non-tumor-bearing dogs (with and without chronic weight loss) (n = 83). Serum T4, T3, and fT3 concentrations were lower (P < .05) in dogs with weight loss, whether or not they were tumor-bearing, than in dogs without weight loss. Serum fT4 concentrations did not vary among the groups. Serum albumin concentrations were lower (P < .05) in cachectic dogs than in dogs not experiencing weight loss, regardless of their tumor-bearing status. Percentage of weight loss was found to be associated (P < .05) with T4, T3, and fT3 concentrations. It appears that the low thyroid hormone concentrations are related to either an abnormal nutritional state or to the severity of illness, rather than to a tumor-related phenomenon.
比较了患肿瘤犬（有或无慢性体重减轻）与非患肿瘤犬（有或无慢性体重减轻）（n = 83）的血清甲状腺素（T4）、3,5,3'-三碘甲状腺原氨酸（T3）、游离甲状腺素（fT4）和游离3,5,3'-三碘甲状腺原氨酸（fT3）浓度。无论是否患肿瘤，体重减轻的犬血清T4、T3和fT3浓度均低于未体重减轻的犬（P <.05）。各组间血清fT4浓度无差异。无论是否患肿瘤，恶病质犬的血清白蛋白浓度均低于未体重减轻的犬（P <.05）。发现体重减轻百分比与T4、T3和fT3浓度相关（P <.05）。低甲状腺激素浓度似乎与异常营养状态或疾病严重程度有关，而非与肿瘤相关现象有关。
