Tamura N, Suzuki K, Iwase A, Yamamoto T, Kira S
Department of Respiratory Medicine, Juntendo University School of Medicine.
Nihon Rinsho. 1994 Jun;52(6):1503-7.
Sarcoidosis is a granulomatous disorder of unknown etiology. Accumulated data suggest that one or several exogenous or altered self antigens participate in producing pathophysiological change in sarcoidosis. Recently, analysis of retroviruses such as HTLV-1 and HIV-1 revealed that these viruses would produce autoimmune disease like symptoms including interstitial lung disease like pulmonary manifestation. We hypothesized novel type retrovirus or retrovirus related antigens might be a putative pathogen for sarcoidosis. Syncytial cell formation or cytopathic effect was observed in 6 of 24 patients (25%) after coculture of sarcoid BALF cells with U937 cells. Five of 18 culture supernatant showed moderate reverse transcriptase activity. Expression of clone 4-1 env protein, one of the endogenous retroviral elements, was also observed in alveolar macrophages of sarcoidosis. These data encourages the further investigation of retrovirus as the pathogen of sarcoidosis.
结节病是一种病因不明的肉芽肿性疾病。累积的数据表明，一种或几种外源性或自身改变的抗原参与了结节病病理生理变化的产生。最近，对人类T淋巴细胞白血病病毒1型（HTLV-1）和人类免疫缺陷病毒1型（HIV-1）等逆转录病毒的分析显示，这些病毒会产生自身免疫性疾病样症状，包括间质性肺病样肺部表现。我们推测新型逆转录病毒或逆转录病毒相关抗原可能是结节病的假定病原体。在结节病支气管肺泡灌洗（BALF）细胞与U937细胞共培养后，24例患者中有6例（25%）观察到合胞体细胞形成或细胞病变效应。18份培养上清液中有5份显示出中等水平的逆转录酶活性。在结节病的肺泡巨噬细胞中也观察到内源性逆转录病毒元件之一的克隆4-1 env蛋白的表达。这些数据鼓励进一步研究逆转录病毒作为结节病的病原体。
