[成人T细胞白血病病毒I型血清阳性葡萄膜炎患者支气管肺泡灌洗液淋巴细胞亚群的研究]

[Studies of lymphocyte subpopulations of bronchoalveolar lavage fluid in HTLV-I seropositive patients with uveitis].

作者信息

Mukae H, Morikawa T, Kusano S, Sawa H, Sakito O, Morikawa N, Oda H, Kadota J, Kohno S, Hara K

机构信息

Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan.

出版信息

Nihon Kyobu Shikkan Gakkai Zasshi. 1993 Nov;31(11):1397-404.

PMID:8277609

Abstract

To determine whether HTLV-I infection is associated with uveitis, we investigated the bronchoalveolar lavage fluid (BALF) cells in 23 patients with uveitis. Of these, sarcoidosis was diagnosed in 13 patients, but could not be confirmed in the remaining 10 patients (non-sarcoidosis). Three of 13 patients (23.1%) with sarcoidosis and 7 of 10 non-sarcoidosis patients (70.0%) were HTLV-I seropositive. In BALF, no significant differences were observed between the HTLV-I seropositive and seronegative patients. However, in non-sarcoidosis patients, total cell counts, CD3+ and CD+ HLA-DR+ cells in BALF were significantly higher in seropositive patients than in seronegative patients. CD3+ CD25+ cells in BALF were markedly increased in 3 of 7 non-sarcoidosis seronegative patients. These findings indicated that BALF lymphocytes in HTLV-I seropositive non-sarcoidosis patients were more activated than those in seronegative non-sarcoidosis patients, supporting the hypothesis that HTLV-I infection may be associated with uveitis.

摘要

为了确定人类嗜T淋巴细胞病毒I型（HTLV-I）感染是否与葡萄膜炎相关，我们调查了23例葡萄膜炎患者的支气管肺泡灌洗液（BALF）细胞。其中，13例患者被诊断为结节病，其余10例患者（非结节病）无法确诊。13例结节病患者中有3例（23.1%）HTLV-I血清学阳性，10例非结节病患者中有7例（70.0%）HTLV-I血清学阳性。在BALF中，HTLV-I血清学阳性和血清学阴性患者之间未观察到显著差异。然而，在非结节病患者中，血清学阳性患者BALF中的总细胞计数、CD3+和CD+HLA-DR+细胞显著高于血清学阴性患者。7例非结节病血清学阴性患者中有3例BALF中的CD3+CD25+细胞明显增加。这些发现表明，HTLV-I血清学阳性的非结节病患者的BALF淋巴细胞比血清学阴性的非结节病患者的更活跃，支持HTLV-I感染可能与葡萄膜炎相关的假说。