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[肺结节病的皮质类固醇治疗]

[Corticosteroid treatment in pulmonary sarcoidosis].

作者信息

Ohmichi M, Yamada G, Hiraga Y

机构信息

Department of Respiratory Diseases, Sapporo Hospital of Hokkaido Railway Company.

出版信息

Nihon Rinsho. 1994 Jun;52(6):1643-7.

PMID:8046856
Abstract

Indication, dose and duration of corticosteroids in treating pulmonary sarcoidosis have discussed. Although corticosteroids are effective in improving the chest X-ray findings of sarcoidosis patients with in short term treatment, it is doubtful that corticosteroids affects the clinical course of sarcoidosis and are beneficial with long term treatment. It is agreed that asymptomatic patients with Stage I should not be treated while symptomatic patients with Stage II and Stage III should be treated. Asymptomatic patients with Stage II and Stage III need to be followed closely. The initial dose of treatment is 30 mg prednisone daily, and this is gradually reduced to the maintenance level of 10 to 15 mg. The total duration of prednisolone treatment is about 1.5 year or even more.

摘要

已讨论了皮质类固醇治疗肺结节病的适应证、剂量和疗程。尽管皮质类固醇在短期治疗中能有效改善结节病患者的胸部X线表现,但皮质类固醇是否会影响结节病的临床病程以及长期治疗是否有益仍存疑问。目前达成的共识是,I期无症状患者不应接受治疗,而II期和III期有症状的患者应接受治疗。II期和III期无症状患者需要密切随访。初始治疗剂量为每日30毫克泼尼松,然后逐渐减至10至15毫克的维持剂量。泼尼松龙治疗的总疗程约为1.5年甚至更长。

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