Maes M, Lambrechts J, Suy E, Vandervorst C, Bosmans E
Department of Psychiatry, University Hospitals of Cleveland, Ohio.
Neuropsychobiology. 1994;29(4):157-63. doi: 10.1159/000119080.
One of the most consistently reported immunological abnormalities in major depression is blunted ex vivo natural killer cell activity (NKCA). This study was designed to investigate the number and percentage of circulating natural killer cells (NKC) in a group of patients with unipolar depression. In addition, the number and percentage of other phagocytic/cytotoxic cells were determined. The following cell subsets were investigated: number of leukocytes, monocytes, neutrophils, lymphocytes, NKC (CD16+ or CD56+), and non-MHC-restricted cytotoxic T lymphocytes (CTL) in 17 healthy controls and 79 depressed subjects. There were no differences either in absolute number or percentage of NKC, or CTL between healthy controls, minor, simple major, and melancholic depressed subjects. Depression per se was characterized by a leukocytosis due to monocytosis and neutrophilia. Our results do not support the thesis that depression-related blunted NKCA is caused by a decreased number or percentage of NKC in peripheral blood.
重度抑郁症中最常被报道的免疫异常之一是体外自然杀伤细胞活性（NKCA）减弱。本研究旨在调查一组单相抑郁症患者循环自然杀伤细胞（NKC）的数量和百分比。此外，还测定了其他吞噬/细胞毒性细胞的数量和百分比。研究了以下细胞亚群：17名健康对照者和79名抑郁症患者的白细胞、单核细胞、中性粒细胞、淋巴细胞、NKC（CD16+或CD56+）以及非MHC限制性细胞毒性T淋巴细胞（CTL）的数量。健康对照者、轻度、单纯重度和抑郁性抑郁症患者之间的NKC或CTL的绝对数量或百分比均无差异。抑郁症本身的特征是由于单核细胞增多和中性粒细胞增多导致白细胞增多。我们的结果不支持抑郁症相关的NKCA减弱是由外周血中NKC数量或百分比减少引起的这一论点。
