Struthers C S
Glenbrook Hospital, Glenview, IL.
Oncol Nurs Forum. 1994 May;21(4):677-83; quiz 684-5.
To describe the pathophysiology and nursing care of patients with Lambert-Eaton myasthenic syndrome (LEMS), a little-known paraneoplastic syndrome.
Published articles, books and book chapters, and clinical trial experience.
LEMS most commonly is associated with small cell lung cancer. Clinical presentation is characterized by weakness of the proximal muscles of the pelvis, thighs, shoulders, and arms and a weakening or absence of deep tendon reflexes. These symptoms are the manifestations of an abnormality at the neuromuscular junction and may precede the diagnosis of lung cancer.
The oncology nurse knowledgeable about the pathophysiology, clinical features, diagnostic evidence, and treatment of LEMS is better able to care for and teach patients with this disorder.
Nurses must assist patients in adjusting not only to a diagnosis of cancer and its treatment effects but also to the symptoms of LEMS, including impaired mobility, self-care deficits, and fatigue.
描述兰伯特-伊顿肌无力综合征（LEMS）这一鲜为人知的副肿瘤综合征患者的病理生理学及护理。
发表的文章、书籍及书籍章节，以及临床试验经验。
LEMS最常与小细胞肺癌相关。临床表现以骨盆、大腿、肩部及手臂近端肌肉无力以及深部腱反射减弱或消失为特征。这些症状是神经肌肉接头处异常的表现，可能在肺癌诊断之前出现。
熟悉LEMS病理生理学、临床特征、诊断依据及治疗的肿瘤专科护士能更好地护理和教导患有该疾病的患者。
护士必须协助患者不仅适应癌症诊断及其治疗效果，还要适应LEMS的症状，包括活动能力受损、自我护理缺陷及疲劳。
