Schmitz-Moormann P
Virchows Arch A Pathol Anat Histol. 1975;365(3):263-5. doi: 10.1007/BF00434044.
Two groups of mice (A/J/Han) were treated with casein for 3 weeks. They then received chondroitin sulfate for 1 week, the one group subcutaneously and the other intraperitoneally. Intraperitoneally, chondroitin sulfate produces a more pronounced amyloidosis than subcutaneously. It also causes a marked amyloidosis of the draining lymph nodes of the abdomen. These alterations probably result from an unspecific amyloidogenic effect of chondroitin sulfate, which becomes stronger as local concentration increases.
两组（A/J/Han）小鼠用酪蛋白处理3周。然后它们接受硫酸软骨素处理1周，一组皮下注射，另一组腹腔注射。腹腔注射时，硫酸软骨素比皮下注射产生更明显的淀粉样变性。它还会导致腹部引流淋巴结出现明显的淀粉样变性。这些改变可能是由于硫酸软骨素的非特异性淀粉样变性作用引起的，随着局部浓度的增加，这种作用会更强。
