顺铂和卡铂与聚氯乙烯输液袋的稳定性及相容性

Stability and compatibility of cisplatin and carboplatin with PVC infusion bags.

作者信息

Benaji B, Dine T, Luyckx M, Brunet C, Goudaliez F, Mallevais M L, Cazin M, Gressier B, Cazin J C

机构信息

Laboratoire de Pharmacologie, Pharmacocinétique et Pharmacie Clinique, Faculté des Sciences Pharmaceutiques et Biologiques de Lille, France.

出版信息

J Clin Pharm Ther. 1994 Apr;19(2):95-100. doi: 10.1111/j.1365-2710.1994.tb01118.x.

DOI:10.1111/j.1365-2710.1994.tb01118.x

PMID:8071399

Abstract

The availability and compatibility of drugs from solutions infused via PVC infusion bags through PVC administration sets have been examined. No significant drug loss was observed during simulated infusions using PVC infusion bags and administration sets over time periods used in hospitals (cisplatin, 2 h; carboplatin, 1 h). The stability of carboplatin was studied in 5% dextrose. In 0.9% NaCl, we observed that carboplatin could be converted to cisplatin in the presence of chloride ions. With cisplatin, no significant difference was found between infusion solutions (5% dextrose or 0.9% NaCl). The stability of cisplatin (5% dextrose or 0.9% NaCl) and carboplatin (5% dextrose) was also studied in PVC bags after storage in the dark at room temperature. The results show that the drugs were stable over the 9-day storage period studied.

摘要

已对通过聚氯乙烯（PVC）输液袋经PVC给药装置输注的溶液中的药物可用性和兼容性进行了研究。在医院使用的时间段内（顺铂，2小时；卡铂，1小时），使用PVC输液袋和给药装置进行模拟输注期间，未观察到明显的药物损失。研究了卡铂在5%葡萄糖中的稳定性。在0.9%氯化钠中，我们观察到在氯离子存在的情况下，卡铂可转化为顺铂。对于顺铂，输注溶液（5%葡萄糖或0.9%氯化钠）之间未发现显著差异。还研究了顺铂（5%葡萄糖或0.9%氯化钠）和卡铂（5%葡萄糖）在室温黑暗条件下储存在PVC袋中的稳定性。结果表明，在所研究的9天储存期内，药物是稳定的。