Oades R D, Schepker R
RLHK Clinic for Child and Adolescent Psychiatry, University of Essen, Germany.
Psychoneuroendocrinology. 1994;19(4):373-85. doi: 10.1016/0306-4530(94)90017-5.
Psychosis is reported to show a later age of onset in women than in men and its nature and course in women may also differ. The purpose of this study was to determine if levels of four steroid hormones at the start of early onset psychosis differ from the levels of other groups of young people and if predicted low levels of estrogen (E2) are a feature of female psychosis. Two blood samples from 22 young psychotic patients were analysed by radioimmunoassay for E2, progesterone (PROG), testosterone (TE), and dehydroepiandrosterone sulphate (DHEAS). Female psychotic patients showed E2 levels lower than matched healthy cycling controls but higher than those on a contraceptive pill; they also showed higher TE levels than controls. Male psychotic patients had higher DHEAS levels than healthy or obsessive compulsive disorder (OCD) subjects. We suggest that illness-related changes of steroids can be measured superimposed on medication-induced changes and that lower E2 levels in psychotic women may increase their vulnerability to psychosis. Changes of TE in female and DHEAS in male psychotics may be more a consequence of the illness.
据报道，精神病的发病年龄女性比男性晚，而且其在女性中的性质和病程可能也有所不同。本研究的目的是确定早发性精神病开始时四种类固醇激素的水平是否与其他年轻人群体的水平不同，以及预测的低雌激素（E2）水平是否为女性精神病的一个特征。通过放射免疫分析法对22名年轻精神病患者的两份血样进行了E2、孕酮（PROG）、睾酮（TE）和硫酸脱氢表雄酮（DHEAS）分析。女性精神病患者的E2水平低于匹配的健康周期对照组，但高于服用避孕药的对照组；她们的TE水平也高于对照组。男性精神病患者的DHEAS水平高于健康或强迫症（OCD）受试者。我们认为，可以在药物诱导变化的基础上测量与疾病相关的类固醇变化，并且精神病女性中较低的E2水平可能会增加她们患精神病的易感性。女性精神病患者中TE的变化以及男性精神病患者中DHEAS的变化可能更多是疾病的结果。
