Martínez-Gómez F
Departamento de Parasitología E.N.C.B. del I.P.N., México, D.F., Mexico.
Rev Latinoam Microbiol. 1993 Jul-Sep;35(3):319-25.
Malaria continues as a public health problem in the world. The control strategy by insecticides against the vector arthropod and antimalaria drugs have not been enough to eradicate this illness, which is the cause of over a million deaths every year throughout the world. In the latest years the recombinant DNA technology and the synthesis of peptides for antimalaria vaccine elaboration has been used specially against Plasmodium falciparum, which is the most aggressive of the human species of Plasmodium. Encouraging results in this field have been obtained. Some molecules have been characterized and synthetized which are considered worthy vaccine candidates because of their suitable immunogenicity, safety and immunoprotective capacity. These molecules belong to sexual and merozoite phases of the parasite, meanwhile molecules isolated from the sporozoitic phase, such as circunsporozoitic protein, have posed the greatest problems for the vaccine development.
疟疾仍是全球的一个公共卫生问题。通过杀虫剂控制病媒节肢动物以及使用抗疟疾药物的控制策略，尚不足以根除这种疾病，它每年在全球导致超过一百万人死亡。近年来，重组DNA技术以及用于研制抗疟疾疫苗的肽合成技术，已特别用于对抗恶性疟原虫，它是疟原虫属中对人类最具侵袭性的物种。在这一领域已取得了令人鼓舞的成果。一些分子已得到表征和合成，因其具有合适的免疫原性、安全性和免疫保护能力，被认为是有价值的疫苗候选物。这些分子属于疟原虫的有性阶段和裂殖子阶段，与此同时，从子孢子阶段分离出的分子，如环子孢子蛋白，给疫苗研发带来了最大的问题。
