Naume B, Espevik T
Norwegian Radium Hospital, Oslo.
Scand J Immunol. 1994 Aug;40(2):128-34. doi: 10.1111/j.1365-3083.1994.tb03441.x.
Natural killer (NK) cells are able to kill tumour cells or virus-infected cells spontaneously and independent of classical MHC-restriction. The activities of these cells can be regulated by different cytokines. Interleukin-2 has been shown to be a potent stimulatory factor for NK cells, inducing proliferation, cytokine production and increased cytotoxic activity. During recent years, the influence of various cytokines on NK cells have been studied, like interferons, IL-1, IL-6, IL-4 and TGF-beta. Recently, new cytokines like IL-7 and IL-12 have been shown to possess direct and potent stimulatory effects on NK cells. Furthermore, endogenous production of TNF seems to play an important role in mediating effects induced by several stimulatory cytokines. Here, an overview of the different regulatory effects of these cytokines on NK cells are presented.
自然杀伤（NK）细胞能够自发地杀死肿瘤细胞或病毒感染细胞，且不依赖于经典的MHC限制。这些细胞的活性可由不同的细胞因子调节。白细胞介素-2已被证明是NK细胞的一种有效刺激因子，可诱导增殖、细胞因子产生并增强细胞毒性活性。近年来，人们研究了各种细胞因子对NK细胞的影响，如干扰素、IL-1、IL-6、IL-4和转化生长因子-β。最近，已证明新的细胞因子如IL-7和IL-12对NK细胞具有直接且有效的刺激作用。此外，肿瘤坏死因子的内源性产生似乎在介导几种刺激细胞因子诱导的效应中起重要作用。在此，本文将概述这些细胞因子对NK细胞的不同调节作用。
