Forster R K, Rebell G
Am J Ophthalmol. 1975 Mar;79(3):510-5. doi: 10.1016/0002-9394(75)90629-7.
Because of the frequency of fungal keratitis due to Fusarium solani, we needed a sustained, progressive infection in an animal model to determine the mechanisms of pathogenicity and to evaluate the new antifungal agents. Pigmented rabbits interlamellarly injected with actively germinating conidia from lyophilized temperature-tolerant strains of F. solani produced sustained culture-positive ulcers in high percentage of eyes at two and three weeks, pretreatment with subconjunctival corticosteroids was necessary. Histopathology, although a poor index of infectivity since some corneas with plentiful hyphal fragments had negative cultures, simulated human fungal pathology.
由于茄病镰刀菌导致的真菌性角膜炎发病率较高，我们需要在动物模型中建立持续、进行性感染，以确定其致病机制并评估新型抗真菌药物。用冻干的耐温茄病镰刀菌菌株的活跃萌发分生孢子进行层间注射的有色家兔，在两到三周时，高比例的眼睛出现持续培养阳性溃疡，结膜下皮质类固醇预处理是必要的。组织病理学虽然由于一些有大量菌丝片段的角膜培养结果为阴性而不是感染性的良好指标，但模拟了人类真菌病理学。
