Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH, USA.
Cytokine. 2012 Apr;58(1):107-11. doi: 10.1016/j.cyto.2011.12.022. Epub 2012 Jan 26.
Fungal infections of the cornea are an important cause of blindness and visual impairment worldwide, with contact lens wear being the main risk factor in the USA and other industrialized countries, and traumatic injury being the main risk factor in developing countries. In this review, we highlight recent advances in the understanding of the host response to Aspergillus and Fusarium species in infected human corneal tissue and in mouse models of fungal keratitis.
角膜真菌感染是全球范围内导致失明和视力损害的重要原因，在美国和其他工业化国家，隐形眼镜的佩戴是主要的危险因素，而在发展中国家，创伤性损伤是主要的危险因素。在这篇综述中，我们强调了对受感染人眼角膜组织中宿主对曲霉菌属和镰刀菌属物种的反应以及真菌性角膜炎小鼠模型的理解方面的最新进展。
