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[亚致死剂量亚硝酸钠对大鼠肝脏线粒体呼吸及氧化磷酸化的影响]

[Effect of a sublethal dose of sodium nitrite on respiration and oxidative phosphorylation in the rat liver mitochondria].

作者信息

Babs'kyĭ A M, Stefankiv Iu S, Korobov V M

出版信息

Ukr Biokhim Zh (1978). 1993 Nov-Dec;65(6):106-8.

PMID:8048174
Abstract

A sublethal dose of sodium nitrates (60 mg/kg) 30 min after intraperitoneal administration to rats increases ADP-stimulated respiration, when succinate is used as the substrate. Its stimulating action is associated with an increase of efficiency of oxygen utilization. Intraperitoneal administration of succinic acid in a dose of 25 mg/kg normalizes changes induced by nitrites. Stress and hypoxic factors in the action of nitrites on aerobic processes in mitochondria are discussed.

摘要

给大鼠腹腔注射亚硝酸钠(60毫克/千克)30分钟后给予亚致死剂量,当以琥珀酸作为底物时,可增加二磷酸腺苷(ADP)刺激的呼吸作用。其刺激作用与氧利用效率的提高有关。腹腔注射25毫克/千克剂量的琥珀酸可使亚硝酸盐引起的变化恢复正常。文中讨论了亚硝酸盐作用于线粒体需氧过程中的应激和缺氧因素。

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