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[硝酸钠对新生大鼠和成年大鼠肝脏线粒体氧化磷酸化的影响]

[Effect of sodium nitrate on oxidative phosphorylation in liver mitochondria of newborn and adult rats].

作者信息

Lavrushenko L F, Tsyganenko O I

出版信息

Ukr Biokhim Zh (1978). 1996 Jan-Feb;68(1):104-7.

PMID:8755113
Abstract

Oxidative phosphorylation in the liver mitochondria of new-born and adult rats has been studied as affected by nitrates. It was established that the conjugation between the processes of respiration and phosphorylation is disturbed, energy efficiency of respiration in the liver mitochondria decreases in the new-born and adult animals. The found disturbances are more distinct in the new-borns that is evidenced by the dose-dependent effect under nitrate intoxications established in this group of animals.

摘要

研究了硝酸盐对新生大鼠和成年大鼠肝脏线粒体氧化磷酸化的影响。结果表明,呼吸过程与磷酸化过程之间的偶联受到干扰,新生动物和成年动物肝脏线粒体呼吸的能量效率降低。在新生动物中发现的这些干扰更为明显,这在该组动物中建立的硝酸盐中毒剂量依赖性效应中得到了证实。

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