Kaltenbach F J, Wilhelm C
Frauenklinik, Universität Freiburg.
Zentralbl Gynakol. 1994;116(6):340-3.
Proteinuria in preeclamptic women was qualitatively differentiated and in cases of pure glomerular proteinuria three groups according to the low-, medium- or high selectivity of glomerular proteinuria were formed. In these patients the incidence of liver dysfunction and severe proteinuria together with an increase in mean arterial blood pressure was investigated. The aim of this study was to find out if there is any connection between glomerular proteinuria of different selectivity and disturbed liver function. In patients with EPH-gestosis a pure glomerular proteinuria in SDS-PAA-disc electrophoresis of the urine was found. Together with the increase in glomerular selectivity an increase in quantitative urinary protein loss was found. In patients with high selective glomerular proteinuria the extent of proteinuria was about three times higher than in patients with low selectivity. In all patients a moderate elevation of the liver enzymes was found. In all patients disturbed liver function returned to normal within a few days after delivery. We conclude from these data that glomerular functional lesions pregnancy in patients with preexisting glomerulopathies or pregnancy induced renal dysfunction are accompanied in a high rate by moderate disorders of liver function.
对先兆子痫女性的蛋白尿进行了定性区分，对于单纯肾小球性蛋白尿的病例，根据肾小球蛋白尿的低、中或高选择性分为三组。研究了这些患者肝功能障碍、严重蛋白尿以及平均动脉血压升高的发生率。本研究的目的是查明不同选择性的肾小球蛋白尿与肝功能紊乱之间是否存在任何关联。在EPH妊娠高血压综合征患者的尿液SDS-PAA圆盘电泳中发现了单纯肾小球性蛋白尿。随着肾小球选择性的增加，定量尿蛋白丢失也增加。高选择性肾小球蛋白尿患者的蛋白尿程度比低选择性患者高约三倍。所有患者均发现肝酶中度升高。所有患者的肝功能紊乱在分娩后几天内恢复正常。我们从这些数据得出结论，在患有既往肾小球疾病或妊娠诱发肾功能障碍的患者中，肾小球功能损害在妊娠期间常伴有中度肝功能障碍。
