Osadchaia O V, Nazarenko L G, Bobritskaia V V
Akush Ginekol (Mosk). 1993(2):16-20.
The clinical efficacy of various vasodilators characterized by different direction of the hemodynamic action (arteriolar, mixed, venous) was assessed in therapy of the slight and medium-severe hypertensive syndrome in 92 pregnant women aged 19-36 at pregnancy terms of 24 to 39 weeks. The drugs were administered as monotherapy. Twenty-two healthy women with the normal gestation process made up the reference group. Echocardiograms have shown before the course of treatment the hyper-, hypo-, and eukinetic changes in the hemodynamics (26, 31, 35 cases, respectively). Venodilators (sustonit-mitte) were found the most effective in the pregnant women with the hyperkinetic type of circulation; in patients with the eu- and hypokinetic type both mixed vasodilators and the arteriolodilators (prazosin, cordafen) were effective. Venodilators are not recommended for patients with the hyperkinetic circulation type because of an undesirable reduction of myocardial contractility.
对92名年龄在19至36岁、孕期为24至39周的孕妇，评估了以不同血液动力学作用方向（小动脉、混合、静脉）为特征的各种血管扩张剂在轻度和中度重度高血压综合征治疗中的临床疗效。这些药物作为单一疗法给药。22名妊娠过程正常的健康女性组成对照组。超声心动图显示，在治疗过程开始前，血液动力学存在高动力、低动力和正常动力变化（分别为26例、31例和35例）。发现静脉扩张剂（苏斯托尼 - 米特）对高动力型循环的孕妇最有效；对正常动力型和低动力型患者，混合血管扩张剂和小动脉扩张剂（哌唑嗪、科达芬）均有效。由于会导致心肌收缩力意外降低，不建议高动力循环型患者使用静脉扩张剂。
