Ward K M, Mahan J D, Sherman W M
College of Medicine, School of Allied Medical Professions, Ohio State University Columbus 43210.
Ann Clin Lab Sci. 1994 May-Jun;24(3):266-77.
The effects of aerobic exercise training on diabetes control and the development of renal microvascular disease were studied in the obese Zucker rat, an animal model of noninsulin dependent diabetes mellitus (NIDDM). Training consisted of 12 weeks of treadmill running, beginning at six weeks of age. Eight trained obese Zucker rats were compared to 15 obese sedentary controls and to 22 sedentary lean nondiseased littermates. Fasting blood glucose, percent of glycated hemoglobin, serum insulin, serum total cholesterol, body weight and kidney weight, creatinine clearance, urine total protein excretion, urine albumin excretion, and morphometric analyses of cortical glomeruli by light and electron microscopy were performed to evaluate metabolic control, renal function, and structure. Training was associated with less albuminuria, less mesangial volume expansion, and less glomerular basement membrane thickening compared to obese sedentary NIDDM animals. These results suggest that exercise training reduces the glomerular ultrastructural lesions and attenuates the albumin excretion rate in this rat model of obesity-related diabetes.
在肥胖 Zucker 大鼠（一种非胰岛素依赖型糖尿病（NIDDM）动物模型）中研究了有氧运动训练对糖尿病控制及肾微血管疾病发展的影响。训练从六周龄开始，包括 12 周的跑步机跑步。将八只经过训练的肥胖 Zucker 大鼠与 15 只肥胖久坐不动的对照大鼠以及 22 只久坐不动的非患病瘦同窝仔鼠进行比较。进行空腹血糖、糖化血红蛋白百分比、血清胰岛素、血清总胆固醇、体重和肾脏重量、肌酐清除率、尿总蛋白排泄、尿白蛋白排泄以及通过光镜和电镜对皮质肾小球进行形态计量分析，以评估代谢控制、肾功能和结构。与肥胖久坐不动的 NIDDM 动物相比，训练与较少的蛋白尿、较少的系膜体积扩张和较少的肾小球基底膜增厚有关。这些结果表明，运动训练可减少该肥胖相关糖尿病大鼠模型中的肾小球超微结构病变并降低白蛋白排泄率。
