Chiasera J M, Ward-Cook K M, McCune S A, Wardlaw G M
Medical Technology Division, Ohio State University, Columbus 43210, USA.
Ann Clin Lab Sci. 2000 Oct;30(4):346-53.
The effect of aerobic exercise intervention on the renal functional and ultrastructural changes associated with diabetes mellitus were studied in the obese Zucker rat, a rat model of type 2 diabetes. The obese Zucker rats began training at 18 wk of age (n=8) and were compared to obese sedentary controls (n=12) and lean sedentary nondiseased littermates (n=10). Body weight, kidney weight, serum creatinine, urine creatinine, creatinine clearance, urine IgG, urine IgG/creatinine ratio, urine total protein, urine albumin, urine albumin/creatinine ratio, glycated hemoglobin, serum fructosamine, fasting serum glucose, serum insulin, serum total cholesterol, serum triglycerides, blood pressure, and morphometric analyses of cortical glomeruli by light microscopy and electron microscopy were performed to evaluate renal function, structure, and metabolic control. The exercise training consisted of treadmill running, 5 da/wk for 1 hr/da. Exercise intervention lowered the body weight (p <0.05), reduced the percentage of glycated hemoglobin (p <0.05), and diminished the urine albumin concentration (p <0.05), compared to the obese sedentary controls. Exercise intervention did not significantly affect morphometric indices of renal ultrastructure. This study shows that aerobic exercise intervention significantly improved metabolic control and reduced albuminuria in a rat model of type 2 diabetes.
在肥胖 Zucker 大鼠（一种 2 型糖尿病大鼠模型）中研究了有氧运动干预对与糖尿病相关的肾功能和超微结构变化的影响。肥胖 Zucker 大鼠在 18 周龄时开始训练（n = 8），并与肥胖久坐不动的对照组（n = 12）和瘦的久坐不动的非患病同窝仔鼠（n = 10）进行比较。测量了体重、肾脏重量、血清肌酐、尿肌酐、肌酐清除率、尿 IgG、尿 IgG/肌酐比值、尿总蛋白、尿白蛋白、尿白蛋白/肌酐比值、糖化血红蛋白、血清果糖胺、空腹血清葡萄糖、血清胰岛素、血清总胆固醇、血清甘油三酯、血压，并通过光学显微镜和电子显微镜对皮质肾小球进行形态计量分析，以评估肾功能、结构和代谢控制情况。运动训练包括在跑步机上跑步，每周 5 天，每天 1 小时。与肥胖久坐不动的对照组相比，运动干预降低了体重（p <0.05），降低了糖化血红蛋白百分比（p <0.05），并降低了尿白蛋白浓度（p <0.05）。运动干预对肾脏超微结构的形态计量指标没有显著影响。这项研究表明，有氧运动干预显著改善了 2 型糖尿病大鼠模型的代谢控制并减少了蛋白尿。
