儿科肿瘤学中的每日一次抗生素治疗方案。
Once daily antibiotic regimen in paediatric oncology.
作者信息
Bouffet E, Fuhrmann C, Frappaz D, Couillioud D, Artiges V, Charra C, Bouhour D, Brunat Mentigny M
机构信息
Paediatric Department, Centre L. Bérard, Lyon, France.
出版信息
Arch Dis Child. 1994 Jun;70(6):484-7. doi: 10.1136/adc.70.6.484.
Abstract
The feasibility and efficacy of a once daily antibiotic regimen were assessed in children with malignant tumours. Over a 44 month period, 296 febrile episodes were treated with a regimen of once daily ceftriaxone-amikacin (and teicoplanin or vancomycin if the patient had a central line). The treatment was successful in 272 (92%) episodes without modification of the antibiotic regimen, and only one patient died of uncontrolled sepsis. A once daily antibiotic regimen is therefore feasible and worthwhile in the treatment of febrile episodes in children with cancer.
摘要
对患有恶性肿瘤的儿童采用每日一次抗生素疗法的可行性和疗效进行了评估。在44个月的时间里，296次发热发作采用每日一次头孢曲松 - 阿米卡星疗法进行治疗（如果患者有中心静脉导管，则加用替考拉宁或万古霉素）。272次发作（92%）治疗成功，无需调整抗生素疗法，只有一名患者死于无法控制的败血症。因此，每日一次抗生素疗法在治疗癌症患儿的发热发作方面是可行且值得的。
相似文献
1
Once daily antibiotic regimen in paediatric oncology.儿科肿瘤学中的每日一次抗生素治疗方案。
Arch Dis Child. 1994 Jun;70(6):484-7. doi: 10.1136/adc.70.6.484.
2
Ceftriaxone plus amikacin in a single daily dose as empiric antibiotic therapy in granulocytopenic patients.
J Chemother. 1989 Dec;1(6):413-6. doi: 10.1080/1120009x.1989.11738935.
3
Ceftriaxone alone or in Combination with Teicoplanin in the Management of Febrile Episodes in Neutropenic Children and Adolescents with Cancer on an Outpatient Base.头孢曲松单独或与替考拉宁联合用于门诊治疗癌症中性粒细胞减少儿童和青少年发热性疾病
Klin Padiatr. 1993 Jul-Aug;205(4):295-9. doi: 10.1055/s-2007-1025240.
4
Strategies for cost-containment: once-daily ceftriaxone plus amikacin as empiric therapy for febrile granulocytopenic children with cancer.成本控制策略：一日一次头孢曲松联合阿米卡星作为癌症发热性粒细胞减少儿童的经验性治疗方法。
J Chemother. 1999 Feb;11(1):54-60. doi: 10.1179/joc.1999.11.1.54.
5
Cost-effectiveness of ceftriaxone and amikacin as single daily dose for the empirical management of febrile granulocytopenic children with cancer.头孢曲松和阿米卡星每日单次给药用于癌症发热性粒细胞减少症患儿经验性治疗的成本效益分析
Chemotherapy. 1997 Sep-Oct;43(5):358-66. doi: 10.1159/000239590.
6
Once daily ceftriaxone and gentamicin for the treatment of febrile neutropenia.每日一次使用头孢曲松和庆大霉素治疗发热性中性粒细胞减少症。
Arch Dis Child. 1999 Feb;80(2):125-31. doi: 10.1136/adc.80.2.125.
7
Empirical antibiotic therapy in febrile neutropenic patients with single-daily dose amikacin plus ceftriaxone.发热性中性粒细胞减少患者每日单次剂量阿米卡星加头孢曲松的经验性抗生素治疗。
J Med Assoc Thai. 1993 Jun;76(6):314-8.
8
Efficacy and toxicity of single daily doses of amikacin and ceftriaxone versus multiple daily doses of amikacin and ceftazidime for infection in patients with cancer and granulocytopenia. The International Antimicrobial Therapy Cooperative Group of the European Organization for Research and Treatment of Cancer.每日单次剂量的阿米卡星和头孢曲松与每日多次剂量的阿米卡星和头孢他啶治疗癌症和粒细胞减少症患者感染的疗效和毒性。欧洲癌症研究与治疗组织国际抗菌治疗合作组
Ann Intern Med. 1993 Oct 1;119(7 Pt 1):584-93. doi: 10.7326/0003-4819-119-7_Part_1-199310010-00006.
9
Randomized clinical trial comparing ceftriaxone/amikacin versus ceftazidime/amikacin as initial therapy of febrile episodes in neutropenic patients.比较头孢曲松/阿米卡星与头孢他啶/阿米卡星作为中性粒细胞减少患者发热性发作初始治疗的随机临床试验。
Chemotherapy. 1991;37(5):376-81. doi: 10.1159/000238882.
10
Comparison of cefepime versus ceftriaxone-amikacin as empirical regimens for the treatment of febrile neutropenia in acute leukemia patients.头孢吡肟与头孢曲松-阿米卡星作为急性白血病患者发热性中性粒细胞减少症经验性治疗方案的比较。
Chemotherapy. 2001 Sep-Oct;47(5):381-4. doi: 10.1159/000048547.
引用本文的文献
1
Efficacy and tolerability of extended-interval aminoglycoside administration in pediatric patients.延长给药间隔的氨基糖苷类药物在儿科患者中的疗效和耐受性
Paediatr Drugs. 2002;4(7):469-84. doi: 10.2165/00128072-200204070-00005.
2
Nonparametric population pharmacokinetic analysis of amikacin in neonates, infants, and children.新生儿、婴儿和儿童中阿米卡星的非参数群体药代动力学分析。
Antimicrob Agents Chemother. 2002 May;46(5):1381-7. doi: 10.1128/AAC.46.5.1381-1387.2002.
3
Once daily ceftriaxone and gentamicin for the treatment of febrile neutropenia.每日一次使用头孢曲松和庆大霉素治疗发热性中性粒细胞减少症。
Arch Dis Child. 1999 Feb;80(2):125-31. doi: 10.1136/adc.80.2.125.
本文引用的文献
1
Once-daily vs. continuous aminoglycoside dosing: efficacy and toxicity in animal and clinical studies of gentamicin, netilmicin, and tobramycin.氨基糖苷类药物每日一次给药与持续给药的比较：庆大霉素、奈替米星和妥布霉素的动物及临床研究中的疗效与毒性
J Infect Dis. 1983 May;147(5):918-32. doi: 10.1093/infdis/147.5.918.
2
Third-generation cephalosporins: a critical evaluation.第三代头孢菌素：批判性评价
Clin Pharm. 1984 Jul-Aug;3(4):351-73.
3
Pharmacokinetics of teicoplanin in man after intravenous administration.替考拉宁静脉给药后的人体药代动力学。
J Pharmacokinet Biopharm. 1984 Apr;12(2):119-28. doi: 10.1007/BF01059273.
4
Pharmacokinetic profile of ceftriaxone in man.头孢曲松在人体内的药代动力学特征。
Am J Med. 1984 Oct 19;77(4C):17-25.
5
After empiric therapy: what to do until the granulocyte comes back.经验性治疗后：在粒细胞恢复之前该怎么做。
Rev Infect Dis. 1987 Jan-Feb;9(1):214-9. doi: 10.1093/clinids/9.1.214.
6
Randomized comparison between two ceftazidime-containing regimens and cephalothin-gentamicin-carbenicillin in febrile granulocytopenic cancer patients.含头孢他啶的两种治疗方案与头孢噻吩-庆大霉素-羧苄西林用于发热性粒细胞缺乏癌症患者的随机对照研究。
Antimicrob Agents Chemother. 1986 Jul;30(1):64-8. doi: 10.1128/AAC.30.1.64.
7
A randomized trial comparing ceftazidime alone with combination antibiotic therapy in cancer patients with fever and neutropenia.
N Engl J Med. 1986 Aug 28;315(9):552-8. doi: 10.1056/NEJM198608283150905.
8
Gram-positive infections and the use of vancomycin in 550 episodes of fever and neutropenia.革兰氏阳性菌感染以及万古霉素在550例发热伴中性粒细胞减少症病例中的应用。
Ann Intern Med. 1988 Jan;108(1):30-5. doi: 10.7326/0003-4819-108-1-30.
9
Empiric antibacterial therapy in granulocytopenia induced by cancer chemotherapy.癌症化疗所致粒细胞减少症的经验性抗菌治疗。
Ann Intern Med. 1988 Jan;108(1):134-6. doi: 10.7326/0003-4819-108-1-134.
10
Controversies in the management of febrile neutropenic cancer patients.
Cancer Invest. 1988;6(2):167-84. doi: 10.3109/07357908809077045.
Zotero 插件