Antonello C, Zagotto G, Mobilio S, Marzano C, Gia O, Uriarte E
Dipartimento di Scienze Farmaceutiche, University of Padova, Italy.
Farmaco. 1994 Apr;49(4):277-80.
Three new psoralens with methyl groups on carbons involved in their reactive double bonds (compounds 9-11 in Scheme 1) were synthesized from the corresponding 7-hydroxycoumarins by cyclization of acetonyl derivatives of the latter in an alkaline medium. In preliminary tests, the new methyl-substituted psoralens exhibited considerable interaction in the dark with DNA, good photoreactivity against the macromolecule, and also interesting antiproliferative activity.
