某些金（III）配合物的细胞毒性活性。
Cytotoxic activity of some gold(III) complexes.
作者信息
Cossu F, Matovic Z, Radanovic D, Ponticelli G
机构信息
Istituto di Radiologia, Università di Cagliari, Ospedale Civile, Italy.
出版信息
Farmaco. 1994 Apr;49(4):301-2.
The [Au(N-MeIm)Cl3], [Au(2-MeBO)Cl3] and [Au(2,5-diMeBO)Cl3] complexes (where N-MeIm = N-methylimidazole, 2-MeBO = 2-methylbenzoxazole and 2,5-diMeBO = 2,5-dimethylbenzoxazole), had been previously prepared and characterized by the Author. These compounds, when tested in vitro against murine leukemia cell lines L1210, human ovarian carcinoma A2780 and their sublines L1210/CDDP and A2780/CDDP resistant to cisplatin, in comparison with cisplatin and carboplatin, showed an interesting cytotoxicity, extended to resistant sublines.
[Au(N-甲基咪唑)Cl₃]、[Au(2-甲基苯并恶唑)Cl₃]和[Au(2,5-二甲基苯并恶唑)Cl₃]配合物（其中N-甲基咪唑=N-methylimidazole，2-甲基苯并恶唑=2-methylbenzoxazole，2,5-二甲基苯并恶唑=2,5-dimethylbenzoxazole），此前已由作者制备并表征。与顺铂和卡铂相比，这些化合物在体外针对小鼠白血病细胞系L1210、人卵巢癌A2780及其对顺铂耐药的亚系L1210/CDDP和A2780/CDDP进行测试时，显示出有趣的细胞毒性，且这种毒性扩展到了耐药亚系。
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