Ishikawa Y, Amitani R
Department of Otorhinolaryngology, Nagahama Red Cross Hospital, Japan.
Arch Otolaryngol Head Neck Surg. 1994 Aug;120(8):861-5. doi: 10.1001/archotol.1994.01880320063014.
To investigate nasal and paranasal disease in patients with congenital velopharyngeal insufficiency (CVPI).
Case series.
Patients with CVPI or cleft palate were investigated at Kyoto (Japan) University Hospital.
Consecutive sample (60 patients with CVPI and 333 with cleft palate). No eligibility criteria or sociodemographic features. Random sample (normal subjects).
The incidence of sinusitis and septal deviation, nasal airway resistance, nasal mucociliary function by saccharin test, and ciliary beating frequency were examined. These findings in patients with cleft palate and normal subjects were compared to clarify the features of nasal disease in CVPI.
The incidence of sinusitis in CVPI was 46.7% and approximately equal to that in cleft palate (44.1%). The incidence of septal deviation in CVPI (26.7%) was low and nasal airway resistance was almost normal. In contrast, in patients with bilateral, unilateral, or incomplete cleft palate, the incidence of septal deviation was significantly more frequent (78.9%) than that in CVPI (P < 0.001), and nasal airway resistance was significantly higher than that in CVPI (P < .0001). In patients with submucosal cleft, septal deviation was found in 40.8% and nasal airway resistance was significantly higher than that in CVPI (P < .02). Although saccharin time was significantly prolonged (P < .001) and ciliary beating frequency was significantly lower (P < .005) in patients with cleft palate than in normal subjects, values for these tests in patients with CVPI were normal.
The incidence of sinusitis was high in CVPI. However, the frequency of septal deviation and nasal airway resistance was almost normal. Nasal mucociliary function (saccharin time and ciliary beating frequency) was also normal.
研究先天性腭咽闭合不全（CVPI）患者的鼻腔及鼻窦疾病。
病例系列研究。
日本京都大学医院对CVPI或腭裂患者进行调查。
连续样本（60例CVPI患者和333例腭裂患者）。无入选标准或社会人口统计学特征。随机样本（正常受试者）。
检查鼻窦炎和鼻中隔偏曲的发生率、鼻气道阻力、通过糖精试验评估的鼻黏膜纤毛功能以及纤毛摆动频率。将腭裂患者和正常受试者的这些结果进行比较，以明确CVPI患者鼻腔疾病的特征。
CVPI患者鼻窦炎的发生率为46.7%，与腭裂患者的发生率（44.1%）大致相当。CVPI患者鼻中隔偏曲的发生率（26.7%）较低，鼻气道阻力几乎正常。相比之下，双侧、单侧或不完全性腭裂患者鼻中隔偏曲的发生率（78.9%）显著高于CVPI患者（P<0.001），且鼻气道阻力显著高于CVPI患者（P<0.0001）。黏膜下腭裂患者鼻中隔偏曲的发生率为40.8%，鼻气道阻力显著高于CVPI患者（P<0.02）。尽管腭裂患者的糖精清除时间显著延长（P<0.001），纤毛摆动频率显著降低（P<0.005），但CVPI患者的这些测试值均正常。
CVPI患者鼻窦炎的发生率较高。然而，鼻中隔偏曲和鼻气道阻力的频率几乎正常。鼻黏膜纤毛功能（糖精清除时间和纤毛摆动频率）也正常。
