Fernández Lobato R, Ortega L, Balibrea J L, Torres A J, García-Calvo M, Alvarez Sánchez J A
II Cátedra de Cirugía, Hospital Universitario, San Carlos, Madrid.
Rev Esp Enferm Dig. 1994 May;85(5):339-42.
Secretion of mucoproteins or mucine (MP) have been studied as possible markers in several pathological conditions of the digestive tract, such us colonic polyposis or gastric dysplasia. In the gallbladder (VB) it has been established that form the core of crystalization for the calculi. A study in 100 gallbladders have been made based on the utility of the analysis of the qualitative and quantitative modifications of MP in lithogenesis. It was been determined by histochemical techniques the three main types of MP (neutral, low and high sulphated acid) to evaluate the alterations in the process of lithiasis. Results show a high production of the MP in VB with lithiasis, presenting in 97% a mixed composition of MP (48.9% of 2 types, and 3 types in 46%), without a predominating type in this pathology.
在诸如结肠息肉病或胃发育异常等几种消化道病理状况中，黏蛋白或黏液（MP）的分泌已被作为可能的标志物进行研究。在胆囊（GB）中，已证实其构成结石结晶的核心。基于MP在结石形成过程中定性和定量变化分析的效用，对100个胆囊进行了一项研究。通过组织化学技术确定了MP的三种主要类型（中性、低硫酸化酸性和高硫酸化酸性），以评估结石形成过程中的变化。结果显示，有结石的胆囊中MP产生量很高，97%呈现MP的混合组成（两种类型占48.9%，三种类型占46%），在这种病理状况下没有占主导的类型。
