Marklew S, Smith D P, Mason C S, Old R W
Department of Biological Sciences, University of Warwick, Coventry, UK.
Biochim Biophys Acta. 1994 Aug 2;1218(3):267-72. doi: 10.1016/0167-4781(94)90177-5.
In a search for nuclear receptors that may mediate the teratogenic effects of the potential morphogen, retinoic acid, on the early development of Xenopus we have isolated a novel Xenopus RXR that most closely resembles the mammalian beta-type RXR. Xenopus RXR beta mRNA is expressed throughout early embryogenesis, and functions as an accessory protein to enhance the DNA-binding of other members of the nuclear receptor superfamily.
为了寻找可能介导潜在形态发生素视黄酸对非洲爪蟾早期发育致畸作用的核受体，我们分离出了一种新的非洲爪蟾RXR，它与哺乳动物的β型RXR最为相似。非洲爪蟾RXRβ mRNA在整个早期胚胎发育过程中都有表达，并作为辅助蛋白增强核受体超家族其他成员的DNA结合能力。
