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非洲爪蟾中一种与视黄酸X受体（RXR）相关联的新型核受体超家族成员，与哺乳动物维生素D3受体具有广泛的序列相似性。

A novel nuclear receptor superfamily member in Xenopus that associates with RXR, and shares extensive sequence similarity to the mammalian vitamin D3 receptor.

作者信息

Smith D P, Mason C S, Jones E A, Old R W

机构信息

Department of Biological Sciences, University of Warwick, Coventry, UK.

出版信息

Nucleic Acids Res. 1994 Jan 11;22(1):66-71. doi: 10.1093/nar/22.1.66.

DOI:10.1093/nar/22.1.66
PMID:8127656
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC307747/
Abstract

We report the isolation of xONR1, a novel member of the nuclear receptor superfamily from Xenopus laevis. xONR1 shares a high degree of amino acid sequence identity with the mammalian receptor for 1 alpha, 25-dihydroxy vitamin D3, particularly within the DNA-binding domain, although it does not bind this ligand. xONR1 DNA binding is stimulated by association with retinoid X receptor gamma (RXR gamma).

摘要

我们报告了从非洲爪蟾中分离出核受体超家族的一个新成员xONR1。xONR1与哺乳动物的1α,25 - 二羟基维生素D3受体具有高度的氨基酸序列同一性，特别是在DNA结合结构域内，尽管它不结合这种配体。xONR1的DNA结合通过与视黄酸X受体γ（RXRγ）结合而受到刺激。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0594/307747/3d0f5ac3198d/nar00025-0083-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0594/307747/d350d527f9e4/nar00025-0082-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0594/307747/a5dae15a7de0/nar00025-0083-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0594/307747/3d0f5ac3198d/nar00025-0083-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0594/307747/d350d527f9e4/nar00025-0082-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0594/307747/a5dae15a7de0/nar00025-0083-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0594/307747/3d0f5ac3198d/nar00025-0083-b.jpg

相似文献

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A novel nuclear receptor superfamily member in Xenopus that associates with RXR, and shares extensive sequence similarity to the mammalian vitamin D3 receptor.非洲爪蟾中一种与视黄酸X受体（RXR）相关联的新型核受体超家族成员，与哺乳动物维生素D3受体具有广泛的序列相似性。
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Identification of a new class of steroid hormone receptors.一类新型甾体激素受体的鉴定。
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