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[暴露于有机磷酸酯类胆碱酯酶抑制剂的小鼠和大鼠红细胞的形态学变化]

[Morphologic changes of erythrocytes in mice and rats exposed to organophosphate cholinesterase inhibitors].

作者信息

Prozorovskiĭ V B, Skopichev V G

出版信息

Biull Eksp Biol Med. 1993 Apr;115(4):443-5.

PMID:8049418
Abstract

Initial stages of animal poisoning with phosphacole and carbophos are accompanied by growth of erythrocytes in size and considerable changes of their surface shape, which disappear in 15 min--4 hrs regardless of the remaining cholinesterase activity inhibition. The phenomenon of erythrocytes' deformation is reproducible in in vitro experiments under the conditions of simultaneous inhibition of cholinesterase activity and exposure to acetylcholine with concentration of 1 x 10(-8) M and higher.

摘要

动物摄入甲胺磷和毒死蜱中毒的初始阶段,红细胞会出现体积增大以及表面形状的显著变化,无论胆碱酯酶活性抑制情况如何,这些变化都会在15分钟至4小时内消失。在体外实验中,当胆碱酯酶活性受到抑制且同时暴露于浓度为1×10⁻⁸M及更高的乙酰胆碱时,红细胞变形现象可以重现。

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