Prozorovskiĭ V B, Skopichev V G, Ardab'eba T V, Panov P B
Interlaboratory Group of Scientific Research Institute of Military Medicine, Ministry of Defense of Russian Federation.
Morfologiia. 1997;112(6):60-4.
By method of scanning electron microscopy erythrocyte structure was studied in rats in carbophos poisoning. Following up to 76% acetylcholinesterase inhibition with distinct symptoms of intoxication nearly 30% of erythrocytes were deformed and tended to aggregate. Observation of blood circulation in vessels of pia mater revealed formation of erythrocyte conglomerations in vascular bed. Erythrocytes get stuck in small vessels, disturbing blood microcirculation. Supposedly, obstruction of the smallest vessels with conglomerations is one of the reasons of exotoxic shock development and low efficiency of treatment of carbophos poisoning by means of specific antidotal cholinolytic drugs and cholinesterase reactivators.
采用扫描电子显微镜方法，对受敌百虫中毒的大鼠红细胞结构进行了研究。当乙酰胆碱酯酶抑制率高达76%并出现明显中毒症状时，近30%的红细胞发生变形并趋于聚集。对软脑膜血管中的血液循环进行观察发现，血管床中形成了红细胞聚集体。红细胞滞留在小血管中，扰乱了血液微循环。据推测，聚集体阻塞最小的血管是外毒素性休克发生的原因之一，也是使用特异性解毒抗胆碱药和胆碱酯酶复活剂治疗敌百虫中毒效果不佳的原因之一。
