Howard K, Jaglarz M, Zhang N, Shah J, Warrior R
Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110.
Dev Suppl. 1993:213-8.
Cell migration is a common feature of development. In order to understand more about the factors that control these movements we have embarked on further analysis of the migration of Drosophila germ cells. This process involves passage of the germ cells across the gut primordium and migration toward the mesoderm where the somatic gonad forms. We are particularly interested in the early phase of this migration when the germ cells interact with the amnioproctodeal invagination, the developing gut, before entering into association with the mesoderm. We will summarize the results of our and other studies of these events before describing a number of enhancer trap lines which show expression in the amnioproctodeal invagination during the early phase of germ cell migration. These reveal more about the complexity of this tissue and suggest this tissue is capable of guiding the early phase of germ cell migration.
细胞迁移是发育过程中的一个常见特征。为了更深入了解控制这些运动的因素，我们着手对果蝇生殖细胞的迁移进行进一步分析。这个过程涉及生殖细胞穿过肠道原基并向中胚层迁移，中胚层是体细胞性腺形成的地方。我们特别关注这一迁移的早期阶段，即生殖细胞在与中胚层结合之前，与羊膜直肠内陷（即发育中的肠道）相互作用的阶段。在描述一些增强子陷阱系之前，我们将总结我们自己以及其他关于这些事件的研究结果，这些增强子陷阱系在生殖细胞迁移的早期阶段在羊膜直肠内陷中显示出表达。这些结果揭示了该组织的更多复杂性，并表明该组织能够引导生殖细胞迁移的早期阶段。
