指导黑腹果蝇生殖细胞迁移的基因wunen的鉴定与遗传分析。
Identification and genetic analysis of wunen, a gene guiding Drosophila melanogaster germ cell migration.
作者信息
Zhang N, Zhang J, Cheng Y, Howard K
机构信息
Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110, USA.
出版信息
Genetics. 1996 Jul;143(3):1231-41. doi: 10.1093/genetics/143.3.1231.
Abstract
We describe a novel genetic locus, wunen (wun), required for guidance of germ cell migration in early Drosophila development. Loss of wun function does not abolish movement but disrupts the orientation of the motion causing the germ cells to disperse even though their normal target, the somatic gonad, is well formed. We demonstrate that the product of this gene enables a signal to pass from the soma to the germ line and propose that the function of this signal is to selectively stabilize certain cytoplasmic extensions resulting in oriented movement. To characterize this guidance factor, we have mapped wun to within 100 kb of cloned DNA.
摘要
我们描述了一个新的基因座，wunen（wun），它是果蝇早期发育中生殖细胞迁移导向所必需的。wun功能的丧失并不会消除运动，而是会扰乱运动方向，导致生殖细胞分散，即使它们的正常靶标——体细胞性腺——发育良好。我们证明该基因的产物能使信号从体细胞传递到生殖系，并提出该信号的功能是选择性地稳定某些细胞质延伸，从而导致定向运动。为了表征这种导向因子，我们已将wun定位到100 kb的克隆DNA范围内。
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