Ring J M, Martinez Arias A
Department of Zoology, University of Cambridge, UK.
Dev Suppl. 1993:251-9.
The final pattern of the cuticle of the Drosophila larva depends on the position-specific behaviour of the epidermal cells during their differentiation. This behaviour is dictated, in part, by the relative position of the cells during embryogenesis which allows them to receive and integrate signals from their neighbours. The translation of this 'positional information' into pattern might depend on the activity of genes that are able to integrate the outcome of cell interactions and transfer it to the genes responsible for cell differentiation. Mutations in the gene puckered cause spatially restricted defects during the differentiation of the larval epidermal cells. We present data that suggests puckered may be involved in linking positional information to cell differentiation.
果蝇幼虫表皮角质层的最终模式取决于表皮细胞在分化过程中的位置特异性行为。这种行为部分由胚胎发育过程中细胞的相对位置决定，这使得它们能够接收并整合来自相邻细胞的信号。将这种“位置信息”转化为模式可能依赖于一些基因的活性，这些基因能够整合细胞间相互作用的结果并将其传递给负责细胞分化的基因。褶皱基因（puckered）的突变会在幼虫表皮细胞分化过程中导致空间受限的缺陷。我们提供的数据表明，褶皱基因可能参与将位置信息与细胞分化联系起来。
