Moon R T, Christian J L, Campbell R M, McGrew L L, DeMarais A A, Torres M, Lai C J, Olson D J, Kelly G M
Department of Pharmacology, University of Washington School of Medicine, Seattle 98195.
Dev Suppl. 1993:85-94.
We review evidence that Xenopus Wnts (Xwnts) have activities consistent with their hypothesized roles as secreted signalling factors involved in multiple developmental processes. Transient misexpression of different Xwnts has distinct effects upon early development, and upon the formation of tissues in UV-irradiated embryos. Misexpression of Xwnts also has distinct effects on the in vitro differentiation of blastula cap explants. Cellular responses to Xwnt signals include changes in gap junctional permeability, altered responsiveness to growth factors, and possibly changes in cell adhesion. Current data suggest that a maternal Xwnt- or noggin-like activity is involved in the Nieuwkoop center activity during mesoderm induction, that Xwnt-8 participates in a pathway of differentiation as ventral mesoderm, and that Xwnt-5A is a potential modulator of morphogenetic movements.
我们回顾了相关证据，即非洲爪蟾Wnt蛋白（Xwnts）的活性与其作为参与多种发育过程的分泌信号因子的假设作用一致。不同Xwnts的瞬时错误表达对早期发育以及紫外线照射胚胎中组织的形成具有不同影响。Xwnts的错误表达对囊胚帽外植体的体外分化也有不同影响。细胞对Xwnt信号的反应包括缝隙连接通透性的变化、对生长因子反应性的改变以及可能的细胞黏附变化。目前的数据表明，母体Xwnt或诺金样活性参与中胚层诱导期间的Nieuwkoop中心活性，Xwnt-8参与腹侧中胚层的分化途径，并且Xwnt-5A是形态发生运动的潜在调节因子。
