Murakami T, Haruki K, Seto Y, Kimura T, Shibe K, Minoshiro S
Osaka City Institute of Public Health and Environmental Sciences.
Nihon Koshu Eisei Zasshi. 1994 May;41(5):461-5.
Influenza viruses in outpatients with influenza symptoms in Osaka City were analyzed in an epidemiological surveillance of infectious disease between 1989 and 1993. During influenza epidemics a mixed prevalence of several types of influenza viruses existed. Three types of influenza viruses, AH1, AH3 and B, were isolated during the 1990/1991 season. Remarkably the three types of viruses were discovered in samplings collected on the same day and within a narrow area inside a radius of 800-1,000m from the surveyed hospitals. Different types of viruses were detected between brothers and among school children from same housing complexes. Influenza AH3 viruses detected in 1992/1993 season differed in antigenicity from those detected in the 1990/1991 and 1991/1992 seasons. Therefore it appears that mutation of the AH3 virus contributed to the large-scale influenza epidemic which occurred in the 1992/1993 season.
在1989年至1993年期间，对大阪市有流感症状的门诊患者中的流感病毒进行了传染病流行病学监测分析。在流感流行期间，存在几种类型流感病毒的混合流行情况。在1990/1991季节分离出三种流感病毒，AH1、AH3和B型。值得注意的是，在同一天采集的样本中以及在距被调查医院半径800 - 1000米的狭窄区域内发现了这三种病毒。在兄弟之间以及来自同一住宅小区的学童中检测到了不同类型的病毒。1992/1993季节检测到的流感AH3病毒在抗原性上与1990/1991和1991/1992季节检测到的病毒不同。因此，似乎AH3病毒的变异导致了1992/1993季节发生的大规模流感流行。
