Department of Cell Biology and Molecular Medicine, Rutgers University-New Jersey Medical School, Newark, NJ 07103, USA.
Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Int J Mol Sci. 2021 Jul 9;22(14):7392. doi: 10.3390/ijms22147392.
The occurrence and prevalence of heart failure remain high in the United States as well as globally. One person dies every 30 s from heart disease. Recognizing the importance of heart failure, clinicians and scientists have sought better therapeutic strategies and even cures for end-stage heart failure. This exploration has resulted in many failed clinical trials testing novel classes of pharmaceutical drugs and even gene therapy. As a result, along the way, there have been paradigm shifts toward and away from differing therapeutic approaches. The continued prevalence of death from heart failure, however, clearly demonstrates that the heart is not simply a pump and instead forces us to consider the complexity of simplicity in the pathophysiology of heart failure and reinforces the need to discover new therapeutic approaches.
心力衰竭在美国乃至全球的发病率和患病率仍然居高不下。每 30 秒就有一人死于心脏病。鉴于心力衰竭的重要性，临床医生和科学家一直在寻求更好的治疗策略，甚至是治疗终末期心力衰竭的方法。这种探索导致了许多新型药物甚至基因治疗的临床试验失败。因此，治疗方法也在不断地发生着转变。然而，心力衰竭导致的死亡率持续居高不下，这清楚地表明心脏不仅仅是一个泵，而是迫使我们考虑心力衰竭病理生理学中简单的复杂性，并加强了寻找新治疗方法的必要性。
