青霉素对A组链球菌性咽炎后体液免疫和细胞免疫反应的影响。
Effect of penicillin on the humoral and cellular immune response following group A streptococcal pharyngitis.
作者信息
Zimmerman R A, Klesius P H, Krushak D H, Mathews J H
出版信息
Can J Comp Med. 1975 Apr;39(2):227-30.
The effect of oral and parenteral penicillin on the development of cellular and humoral immune responses in chimpanzees infected with group A streptococcal M-types 1, 5 and 12 was investigated. The interrelationship between type-specific antibody response and enhancement of phagocytic competence of polymorphonuclear neutrophils was documented. Penicillin depressed or suppressed type-specific antibody response depending on the mode and dose of administration, probably because of its effect on the streptococci responsible for antibody stimulation. Penicillin was not demonstrated to have a direct effect on phagocytic ability in vitro. Therefore the primary effect of antibiotic therapy is the indirect relationship to suppression or inhibition of type-specific antibody response to M-protein which results in a diminution of phagocytic competence.
研究了口服和注射青霉素对感染A组1、5和12型M群链球菌的黑猩猩细胞免疫和体液免疫反应发展的影响。记录了型特异性抗体反应与多形核中性粒细胞吞噬能力增强之间的相互关系。青霉素根据给药方式和剂量抑制或压制型特异性抗体反应，这可能是因为其对负责刺激抗体的链球菌有作用。体外实验未证明青霉素对吞噬能力有直接影响。因此，抗生素治疗的主要作用是与抑制对M蛋白的型特异性抗体反应存在间接关系，这导致吞噬能力减弱。
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