D'Addato M, Curti T, Freyrie A, Agus G B, Bertini D, Biasi G
Chair of Vascular Surgery, University of Bologna, Italy.
Cardiovasc Surg. 1994 Apr;2(2):254-8.
The possibility of increasing the resistance of a synthetic vascular graft to intraoperative or immediate postoperative bacterial contamination justifies the interest in methods such as antibiotic bonding or antibiotic soaking. On the basis of this experience and with the aim of testing the efficacy of such a graft, a multicentre experimental study on sheep to compare the susceptibility to infection of Dacron Gelseal grafts (control) versus rifampicin-bonded Dacron Gelseal grafts (treated) following the intravenous infusion of 10(7)-10(8) cells Staphylococcus aureus was conducted. The grafts were implanted in both common carotid arteries of sheep. In a group of 11 animals (group A), a treated and a control graft were implanted in the same animal. In a group of four sheep (group B), only treated or control grafts were implanted in each animal. In group A, 36% of (four of 11) the treated grafts became infected versus 54% (six of 11) of the control prostheses. In group B, none of the treated grafts was infected by the inoculated pathogen, which, by contrast, infected 75% (three of four) of the controls. These observations confirm the recent interest aroused by the possibility of pretreating gelatin-coated Dacron grafts with rifampicin in the prevention of early graft infection.
增强合成血管移植物对术中或术后即刻细菌污染的抵抗力这一可能性，使得人们对诸如抗生素结合或抗生素浸泡等方法产生了兴趣。基于这一经验，并为了测试此类移植物的功效，开展了一项针对绵羊的多中心实验研究，以比较在静脉输注10(7)-10(8)个金黄色葡萄球菌细胞后，涤纶Gelseal移植物（对照）与利福平结合的涤纶Gelseal移植物（处理组）对感染的易感性。将移植物植入绵羊的双侧颈总动脉。在一组11只动物（A组）中，在同一只动物体内植入一个处理过的移植物和一个对照移植物。在一组4只绵羊（B组）中，每只动物仅植入处理过的或对照移植物。在A组中，36%（11只中的4只）的处理过的移植物发生感染，而对照假体为54%（11只中的6只）。在B组中，处理过的移植物均未被接种的病原体感染，相比之下，对照移植物有75%（4只中的3只）被感染。这些观察结果证实了近期人们对用利福平预处理明胶涂层涤纶移植物预防早期移植物感染的可能性所产生的兴趣。
