果蝇中G1-S转录程序的发育控制
Developmental control of a G1-S transcriptional program in Drosophila.
作者信息
Duronio R J, O'Farrell P H
机构信息
Department of Biochemistry and Biophysics, University of California, San Francisco 94143.
出版信息
Development. 1994 Jun;120(6):1503-15. doi: 10.1242/dev.120.6.1503.
Abstract
We have defined a coordinate program of transcription of S-phase genes (DNA polymerase alpha, PCNA and the two ribonucleotide reductase subunits) that can be induced by the G1 cyclin, cyclin E. In Drosophila embryos, this program drives an intricate spatial and temporal pattern of gene expression that perfectly parallels the embryonic program of S-phase control. This dynamic pattern of expression is not disrupted by a mutation, string, that blocks the cell cycle. Thus, the transcriptional program is not a secondary consequence of cell cycle progression. We suggest that developmental signals control this transcriptional program and that its activation either directly or indirectly drives transition from G1 to S phase in the stereotyped embryonic pattern.
摘要
我们已经定义了一个S期基因（DNA聚合酶α、增殖细胞核抗原和两个核糖核苷酸还原酶亚基）转录的协调程序，该程序可由G1期细胞周期蛋白——细胞周期蛋白E诱导。在果蝇胚胎中，这个程序驱动着一种复杂的基因表达时空模式，该模式与S期控制的胚胎程序完美平行。这种动态表达模式不会因阻断细胞周期的“string”突变而受到干扰。因此，转录程序不是细胞周期进程的次要结果。我们认为发育信号控制着这个转录程序，并且其激活直接或间接地驱动了在刻板的胚胎模式中从G1期到S期的转变。
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