Okano M, Masuda S, Narita H, Masushige S, Kato S, Imagawa S, Sasaki R
Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Japan.
FEBS Lett. 1994 Aug 1;349(2):229-33. doi: 10.1016/0014-5793(94)00673-3.
Retinoic acid (RA) stimulated the production of erythropoietin (Epo) in a human hepatoma cell line, HepG2 cells. The stimulation was due to the accumulation of Epo mRNA. The Epo production in HepG2 cells was also dependent on O2 tension for cell culture but the enhancement of Epo production by RA was independent of O2 tension, indicating that RA exerts its effect through a pathway different from O2. Oral administration of RA to the vitamin A-depleted rats elevated the concentration of Epo in serum. These results suggest that RA up-regulates EPO production in vivo as well as in vitro.
视黄酸（RA）可刺激人肝癌细胞系HepG2细胞产生促红细胞生成素（Epo）。这种刺激是由于Epo mRNA的积累。HepG2细胞中Epo的产生也依赖于细胞培养的氧张力，但RA对Epo产生的增强作用与氧张力无关，这表明RA通过一条不同于氧的途径发挥作用。给维生素A缺乏的大鼠口服RA可提高血清中Epo的浓度。这些结果表明，RA在体内和体外均可上调EPO的产生。
