Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, 606, Kyoto, Japan.
Cytotechnology. 1995 Jan;18(1-2):83-91. doi: 10.1007/BF00744323.
We describe possible functions of carbohydrates attached to growth factors and strategies to examine the functions, concentrating on erythropoietin, a major regulator of erythropoiesis. Erythropoietin in erythropoiesis functions as an endocrine hormone; it is produced by kidney cells and transferred into the circulation to hemopoietic sites. In the brain, erythropoietin acts on neurons in a paracrine fashion. Comparison of glycosylation has been made between kidney and brain erythropoietins.
我们描述了连接在生长因子上的碳水化合物的可能功能，以及检查这些功能的策略，重点介绍了红细胞生成素，这是红细胞生成的主要调节剂。在红细胞生成中，红细胞生成素作为一种内分泌激素发挥作用；它由肾脏细胞产生，并转移到循环系统中的造血部位。在大脑中，红细胞生成素以旁分泌的方式作用于神经元。已经对肾脏和大脑中的红细胞生成素进行了糖基化比较。
