[Single dose prevention with cefuroxime in plastic surgery. Control of serum level, efficacy and tolerance].

Clinical efficacy and drug safety of single-shot prophylaxis with Cefuroxime was investigated in a series of 50 elective plastic surgical operations. Serum and tissue concentrations at one hour after application were determined in ten patients undergoing breast reduction. Levels far above the minimum inhibitory concentrations for possible pathogenic bacteria were obtained. No infection occurred. Wound complications not related to wound infection occurred in 12%.