Watkin D S, Wainwright A M, Thompson M H, Leaper D J
Department of Surgery, Southmead Hospital, Westbury-on-Trym, Bristol, United Kingdom.
Eur J Surg. 1995 Jul;161(7):509-11.
To establish the incidence of infection after laparoscopic cholecystectomy, and assess the need for antibiotic prophylaxis.
Prospective open study.
University teaching hospital, United Kingdom.
253 consecutive patients undergoing laparoscopic cholecystectomy between September 1990 and January 1993.
A single intravenous dose of cefuroxime 1.5 g at induction of general anaesthesia.
Infective complications.
Patients were reviewed at two weeks and 12 months. At two weeks there had been two wound infections (one resolved spontaneously and the other required removal of a gallstone from the subcutaneous tissue), two chest infections (treated with antibiotics orally and physiotherapy), and one subhepatic abscess (drained percutaneously under ultrasonographic control). No other complications were reported at 12 months.
Routine antibiotic prophylaxis may be unnecessary during elective laparoscopic cholecystectomy, but a randomised controlled trial is necessary to confirm this.
确定腹腔镜胆囊切除术后感染的发生率，并评估预防性使用抗生素的必要性。
前瞻性开放性研究。
英国大学教学医院。
1990年9月至1993年1月期间连续253例行腹腔镜胆囊切除术的患者。
全身麻醉诱导时静脉注射单剂量头孢呋辛1.5g。
感染性并发症。
在术后两周和12个月时对患者进行复查。两周时出现2例伤口感染（1例自行缓解，另1例需从皮下组织取出胆结石），2例肺部感染（口服抗生素及物理治疗），1例肝下脓肿（在超声引导下经皮引流）。12个月时未报告其他并发症。
择期腹腔镜胆囊切除术期间可能无需常规预防性使用抗生素，但需要进行随机对照试验以证实这一点。
