隐孢子虫病的新潜在疗法：影响药物疗效的变量分析
New potential therapies for cryptosporidiosis: an analysis of variables affecting drug efficacy.
作者信息
Rehg J
机构信息
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.
出版信息
Folia Parasitol (Praha). 1994;41(1):23-6.
PMID:8050751
Abstract
Cryptosporidium parvum, the protozoan responsible for cryptosporidiosis, continues to defy eradication with existing therapies. A review of the anticryptosporidial activity of several drugs in the dexamethasone-immunosuppressed rat model illustrates the multitude of factors that may contribute to the difficulty of assessing a drug's therapeutic efficacy against the protozoan and provides possible explanation for drug failure at the level of host-parasite interaction.
摘要
微小隐孢子虫是引发隐孢子虫病的原生动物，现有疗法仍难以将其根除。对几种药物在接受地塞米松免疫抑制的大鼠模型中的抗隐孢子虫活性进行的综述表明，多种因素可能导致评估药物对该原生动物的治疗效果存在困难，并为宿主 - 寄生虫相互作用层面的药物失效提供了可能的解释。
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