Demling L
Medizinischen Klinik, Universität Erlangen-Nürnberg, Schlüsselfeld.
Fortschr Med. 1994 May 20;112(14):195-6.
The increasing incidence of Crohn's disease over the last 50 years has paralleled the growing use of antibiotics in human and veterinary medicine. Administered at inadequate doses, antibiotics can induce in bacteria a capability for producing toxins. Statistical considerations also indicate that prior antibiotic treatment promotes the development of Crohn's disease. It seems logical to assume that, in persons with a relevant genetic predisposition, this disease is caused by intestinal bacteria, the biological (not morphological) properties of which have been modified by antibiotics.
在过去50年里，克罗恩病发病率的上升与人类医学和兽医学中抗生素使用的增加是并行的。如果使用剂量不足，抗生素会诱导细菌产生毒素的能力。统计学考量也表明，先前的抗生素治疗会促进克罗恩病的发展。似乎有理由假定，对于具有相关遗传易感性的人来说，这种疾病是由肠道细菌引起的，而这些细菌的生物学（而非形态学）特性已被抗生素改变。
