Texas Tech University, El Paso, TX 9905, USA.
Expert Rev Clin Immunol. 2011 Nov;7(6):751-60. doi: 10.1586/eci.11.43.
Although controversial, the use of properly chosen antibiotics in Crohn's disease appears beneficial. Evidence supporting the use of targeted antibiotic therapy comes in two forms: statistical evidence derived from meta-analyses of multiple formal studies and the documented clinical and endoscopic responses in patients treated with antibiotic combinations outside of formal clinical studies. This article reviews evidence from both categories that support the use of properly chosen antibiotic regimens in treating Crohn's disease, comments on the advantages and disadvantages of antibiotic therapy, and attempts to present a unifying hypothesis related to the role of enteric bacteria, mucosal immunity and antibiotic therapy. Relevant studies identified through a Medline search from 1976 to 2011 were assessed for inclusion by two independent observers who resolved any disagreements by consensus. References from all identified articles and recent review articles were cross-checked to ensure a thorough search. Papers were selected based on scientific merit as to which presented original contributions to the results.
虽然存在争议，但在克罗恩病中使用适当选择的抗生素似乎是有益的。支持靶向抗生素治疗的证据有两种形式：来自对多项正式研究进行荟萃分析的统计证据，以及在正式临床研究之外使用抗生素联合治疗的患者的临床和内镜反应记录。本文综述了来自这两个方面的证据，这些证据支持在治疗克罗恩病中使用适当选择的抗生素方案，评论了抗生素治疗的优缺点，并试图提出一个与肠道细菌、黏膜免疫和抗生素治疗相关的统一假设。通过对 1976 年至 2011 年 Medline 搜索确定的相关研究，由两位独立观察者进行评估，以达成共识的方式解决任何分歧。从所有确定的文章和最近的综述文章中交叉核对参考文献，以确保进行了全面的搜索。根据提出原始结果的科学价值选择论文。
